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Subcutaneous Dexmedetomidine for Refractory Symptoms in a Hospice Inpatient Unit
1. Dexmedetomidine by subcutaneous infusion can safely improve refractory pain and agitated delirium in hospice patients while maintaining rousable sedation 2. It may reduce reliance on high-dose opioids/benzodiazepines and, in...
Risk of infection and wound dehiscence after use of prophylactic antibiotics in episiotomy or second degree tear (REPAIR study): single centre, double blind, placebo-controlled randomised trial
1. Prophylactic antibiotics reduced the risk of clinically relevant wound complications but not overall wound complications in women with episiotomies and second-degree tears. Evidence Rating Level: 1 (Excellent) Study Rundown:...
2 Minute Medicine Rewind November 3rd, 2025
Concomitant use of direct oral anticoagulants and interacting antiarrhythmic drugs and the risk of stroke and bleeding among patients with non-valvular atrial fibrillation: a multinational cohort study 1. In non-valvular...
Development of a Clinical Prediction Model for Anastomotic Leakage in Colorectal Surgery
1. An integrative machine learning predictive model based on individual base models can accurately predict the incidence of anastomotic leakage (AL) after colon resection. Evidence Rating Level: 2 (Good) AL...
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Explore the Classics Series™
![ABCD2 Score: Predicting Early Stroke Risk After Transient Ischemic Attack (TIA) [Classics Series]](data:image/svg+xml;nitro-empty-id=ODU1OjE0MTY=-1;base64,PHN2ZyB2aWV3Qm94PSIwIDAgMSAxIiB3aWR0aD0iMSIgaGVpZ2h0PSIxIiB4bWxucz0iaHR0cDovL3d3dy53My5vcmcvMjAwMC9zdmciPjwvc3ZnPg==)
EAST-AFNET 4 Trial: Early Rhythm Control vs Usual Care in Atrial Fibrillation (East AF) [Classics Series]
1. The EAST-AFNET 4 trial (East AF) demonstrated that early rhythm control therapy—including antiarrhythmic drugs or catheter ablation—was associated...
Ablation may reduce stroke risk, death, heart failure hospitalization in patients with atrial fibrillation
1. In this systematic review and meta-analysis, catheter ablation was found to reduce overall risk of ischemic stroke, hospitalization...
Breast cancer survivors may have a lower risk of Alzheimer’s dementia
1. In this retrospective cohort study, breast cancer survivors had a lower risk of Alzheimer’s dementia compared with cancer-free...
Repeated medial branch blocks do not improve pain outcomes for thermal radiofrequency ablation
1. For patients with facet-mediated spine pain that achieve ≥80% pain relief after a medial branch block, a second...
