Fexofenadine and famotidine lack clinical trial evidence for menopausal symptoms
1. The viral combination of fexofenadine and famotidine for menopausal symptoms is built on a plausible histamine hypothesis but has never been tested in a clinical trial, making substitution for...
Lower levels of education and place of birth were associated with non-admission to the intensive care unit in Sweden during COVID-19 pandemic
1. Patients in Sweden with COVID-19 and lower levels of education or of Northwestern European or Northern American descent were at higher risk of non-admission to the intensive care unit...
Newer GLP-1 agents yield substantial weight loss in nondiabetic adults
1. In this updated systematic review, glucagon-like peptide-1 receptor agonists and co-agonists produced substantial weight loss in adults without diabetes, with greater reductions observed with newer agents. 2. Newer agents...
2 Minute Medicine Rewind August 31, 2026
Periprocedural Mortality Risk After Elective Atrial Fibrillation Ablation in Japan 1. The in-hospital mortality rate among patients undergoing elective catheter ablation for atrial fibrillation was low at approximately 0.029%. Evidence...
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Explore the Classics Series™
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EAST-AFNET 4 Trial: Early Rhythm Control vs Usual Care in Atrial Fibrillation (East AF) [Classics Series]
1. The EAST-AFNET 4 trial (East AF) demonstrated that early rhythm control therapy—including antiarrhythmic drugs or catheter ablation—was associated...
ABCD2 Score: Predicting Early Stroke Risk After Transient Ischemic Attack (TIA) [Classics Series]
1. The ABCD2 score is a validated clinical tool that estimates the short-term risk of stroke following a transient...
Child-Pugh Score: Prognosis, Classification & Cirrhosis Staging in Chronic Liver Disease [Classics Series]
1. The Child-Pugh score, derived from five clinical and lab measures (bilirubin, albumin, INR/prothrombin time, ascites, encephalopathy), is widely...
POISE Trial: Perioperative Metoprolol Reduces MI but Increases Stroke & Mortality [Classics Series]
1. In adults undergoing noncardiac surgery, perioperative β-blocker therapy with extended-release metoprolol significantly reduced nonfatal myocardial infarction (MI) risk...
