FDA Approves First DNA Medicine to Reduce Repeat Airway Surgeries
1. The FDA granted Voceryq accelerated approval for the treatment of recurrent respiratory papillomatosis. 2. Among patients using Voceryq in a clinical study, 27% required no surgeries in the first...
First-trimester doxycycline exposure may be linked to higher risk of pregnancy loss
1. In this retrospective cohort study, first-trimester exposure to doxycycline, as opposed to amoxicillin or macrolides, was associated with a greater risk for pregnancy loss in pregnant patients with respiratory...
101-PGC-005 improved hospitalized patients with COVID-19 faster than systemic dexamethasone in topline phase 2/3 results
In a randomized trial of hospitalized adults with COVID-19, 101-PGC-005 improved clinical recovery faster than systemic dexamethasone without added systemic glucocorticoids.
Asundexian reduced ischemic stroke risk by 26% after recent non-cardioembolic stroke or high-risk transient ischemic attack
FDA approved asundexian with antiplatelet therapy after recent non-cardioembolic ischemic stroke or high-risk transient ischemic attack following a trial showing a 26% risk reduction.
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EAST-AFNET 4 Trial: Early Rhythm Control vs Usual Care in Atrial Fibrillation (East AF) [Classics Series]
1. The EAST-AFNET 4 trial (East AF) demonstrated that early rhythm control therapy—including antiarrhythmic drugs or catheter ablation—was associated...
BI-RADS study identifies mammography features with high positive predictive values for carcinoma [Classics Series]
1. Lesions observed in mammography with spiculated margins, linear calcification morphology, irregular shape, segmental calcification distribution, or linear calcification...
Thrombectomy between 6 and 24 hours after acute stroke reduces disability: The DAWN trial [Classics Series]
1. Thrombectomy performed between 6 and 24 hours after onset of acute stroke in patients with a mismatch between...
Ottawa ankle rules reduce the rate of referral for ankle radiography [Classics Series]
1. The Ottawa ankle rules significantly reduced referral for ankle, but not foot, radiography in the emergency department. 2....
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