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Increased local anesthesia volume may not improve pain control in popliteal plexus block following total knee arthroplasty
For popliteal plexus block after total knee arthroplasty, 10 mL of local anesthetic appears sufficient, as 20 mL offers no added benefit in pain control or early functional recovery. Evidence...
Delaying pegfilgrastim administration reduces bone pain in breast cancer patients
1. In this randomized controlled trial, administering pegfilgrastim 72 hours after chemotherapy reduced bone pain compared with 24- or 48-hour dosing in women with stage I–III breast cancer. 2. Patients...
Dietary changes and pharmacologic interventions may prevent recurrent nephrolithiasis
1. In this systematic review, low-strength evidence suggests that increased fluid intake, dietary modification (normal-to-high calcium, low protein, low sodium), and pharmacologic therapies (thiazides, alkali therapy, allopurinol, and acetohydroxamic acid)...
Pyrotinib provides survival benefit in human epidermal growth factor receptor 2-positive metastatic breast cancer when combined with trastuzumab and docetaxel
1. Pyrotinib combined with trastuzumab and docetaxel prolonged progression-free survival compared to placebo combined with trastuzumab and docetaxel in patients with human epidermal growth factor receptor 2 (HER2) positive metastatic...
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EAST-AFNET 4 Trial: Early Rhythm Control vs Usual Care in Atrial Fibrillation (East AF) [Classics Series]
1. The EAST-AFNET 4 trial (East AF) demonstrated that early rhythm control therapy—including antiarrhythmic drugs or catheter ablation—was associated...
Ablation may reduce stroke risk, death, heart failure hospitalization in patients with atrial fibrillation
1. In this systematic review and meta-analysis, catheter ablation was found to reduce overall risk of ischemic stroke, hospitalization...
Breast cancer survivors may have a lower risk of Alzheimer’s dementia
1. In this retrospective cohort study, breast cancer survivors had a lower risk of Alzheimer’s dementia compared with cancer-free...
Repeated medial branch blocks do not improve pain outcomes for thermal radiofrequency ablation
1. For patients with facet-mediated spine pain that achieve ≥80% pain relief after a medial branch block, a second...
