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High-frequency oscillatory ventilation may reduce the incidence of bronchopulmonary dysplasia in neonatal respiratory distress syndrome

March 20, 2026

Development of a risk index for colorectal cancer screening

NeoCol trial: Neoadjuvant chemotherapy does not improve disease-free survival in patients with locally advanced colon cancer

March 20, 2026

1. Neoadjuvant capecitabine-oxaliplatin chemotherapy did not improve three-year disease-free survival compared to upfront surgery in locally advanced colon cancer. 2. An exploratory subgroup analysis revealed that neoadjuvant chemotherapy may reduce...

Hybrid minimally invasive esophagectomy associated with lower complication rates compared to open esophagectomy

Camrelizumab may be safe and effective in the management of locally advanced esophageal squamous cell carcinoma

byAlex Xiangand1 others

March 19, 2026

1. Neoadjuvant immunoradiotherapy with camrelizumab and radiotherapy demonstrated favourable pathologic tumour regression and safety in the management of resectable locally advanced esophageal squamous cell carcinoma (ESCC). Evidence Rating Level: 2...

Burr hole craniotomy for chronic subdural hematoma under local anesthesia may reduce risks of postoperative delirium compared to general anesthesia

byAlex Xiangand1 others

March 18, 2026

1. In patients with chronic subdural hematoma (cSDH) requiring burr hole craniotomy, operation under local anesthesia (LA) was safe, well-tolerated, and associated with significantly reduced risks of postoperative delirium compared...

Implementation of pneumococcal vaccine programs linked to decreased antibiotic prescription

Smallpox therapy tecovirimat not efficacious in treating clade II mpox

byRomila Santraand1 others

March 18, 2026

1. In this phase 3, randomized, placebo-controlled trial, an antiviral medication approved for treating smallpox (tecovirimat) did not accelerate clinical resolution of mpox compared to placebo. 2. Tecovirimat also did...

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Explore the Classics Series™

ABCD2 Score: Predicting Early Stroke Risk After Transient Ischemic Attack (TIA) [Classics Series]

EAST-AFNET 4 Trial: Early Rhythm Control vs Usual Care in Atrial Fibrillation (East AF) [Classics Series]

byMarc Succi

August 27, 2025

1. The EAST-AFNET 4 trial (East AF) demonstrated that early rhythm control therapy—including antiarrhythmic drugs or catheter ablation—was associated...