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Once-weekly oral islatravir-lenacapavir is noninferior to daily HIV therapy
1. In this phase 3 randomized controlled trial, switching to once-weekly oral islatravir-lenacapavir maintained HIV-1 suppression as effectively as continuing once-daily bictegravir-emtricitabine-tenofovir alafenamide. 2. Rates of serious and grade 3...
Weight loss is associated with improved vascular function in patients with metabolic dysfunction-associated steatotic liver disease
1. Short-term dietary weight loss targeting hepatic fat reduction was associated with measurable improvements in arterial stiffness, endothelial function, and cardiovascular risk scores in metabolic dysfunction-associated steatotic liver disease (MASLD)...
Positive psychotherapy may be similarly effective to traditional cognitive behavioural therapy for panic disorder
1. Positive Psychotherapy (PPT) produced anxiety and well-being outcomes statistically comparable to standard CBT, suggesting it may be a viable alternative for patients who do not respond to or prefer...
Brain-predicted age difference may reliably predict dementia progression
1. Brain-predicted age difference (brain-PAD) is a robust, reproducible predictor of dementia progression across two independent estimation methods, and it is most clinically useful in subjective cognitive decline, where it...
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Explore the Classics Series™
EAST-AFNET 4 Trial: Early Rhythm Control vs Usual Care in Atrial Fibrillation (East AF) [Classics Series]
1. The EAST-AFNET 4 trial (East AF) demonstrated that early rhythm control therapy—including antiarrhythmic drugs or catheter ablation—was associated...
Ablation may reduce stroke risk, death, heart failure hospitalization in patients with atrial fibrillation
1. In this systematic review and meta-analysis, catheter ablation was found to reduce overall risk of ischemic stroke, hospitalization...
Breast cancer survivors may have a lower risk of Alzheimer’s dementia
1. In this retrospective cohort study, breast cancer survivors had a lower risk of Alzheimer’s dementia compared with cancer-free...
Repeated medial branch blocks do not improve pain outcomes for thermal radiofrequency ablation
1. For patients with facet-mediated spine pain that achieve ≥80% pain relief after a medial branch block, a second...
