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Maternal use of benzodiazepines and non-benzodiazepine hypnotics is not associated with increased risk of psychiatric
1. Maternal use of benzodiazepines or non-benzodiazepine hypnotics (Z-hypnotics) during pregnancy was not associated with an increased risk of psychiatric disorders in offspring after controlling for shared familial factors. Evidence...
Sparsentan (Filspari) becomes first approved treatment for focal segmental glomerulosclerosis
1. Sparsentan (Filspari) becomes the first approved treatment specifically for focal segmental glomerulosclerosis. 2. Clinical trial data show meaningful reductions in proteinuria, a key marker of disease progression. The FDA...
A non-invasive neurostimulation intervention may improve social communication impairment in children with autism spectrum disorder
1. Five days of accelerated continuous theta burst stimulation (a-cTBS) targeting the left primary motor cortex improved social communication impairment in children with autism spectrum disorder. Evidence Rating Level: 1...
New targeted therapy daraxonrasib improves survival in pancreatic cancer
1. Daraxonrasib significantly improves survival in metastatic pancreatic cancer compared with standard chemotherapy. 2. Strong response rates in combination therapy suggest broader potential across treatment settings. Revolution Medicines announced positive...
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Explore the Classics Series™
EAST-AFNET 4 Trial: Early Rhythm Control vs Usual Care in Atrial Fibrillation (East AF) [Classics Series]
1. The EAST-AFNET 4 trial (East AF) demonstrated that early rhythm control therapy—including antiarrhythmic drugs or catheter ablation—was associated...
Ablation may reduce stroke risk, death, heart failure hospitalization in patients with atrial fibrillation
1. In this systematic review and meta-analysis, catheter ablation was found to reduce overall risk of ischemic stroke, hospitalization...
Breast cancer survivors may have a lower risk of Alzheimer’s dementia
1. In this retrospective cohort study, breast cancer survivors had a lower risk of Alzheimer’s dementia compared with cancer-free...
Repeated medial branch blocks do not improve pain outcomes for thermal radiofrequency ablation
1. For patients with facet-mediated spine pain that achieve ≥80% pain relief after a medial branch block, a second...
