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A novel therapy targeting γ-aminobutyric acid is safe and may be effective in major depressive disorder
1. H3-10353, a novel γ-aminobutyric acid (GABA) positive allosteric modulator, is safe and well-tolerated in healthy patients and those with major depressive disorder (MDD), and demonstrated some therapeutic benefits in...
Intra-arterial alteplase after thrombectomy improves three-month functional recovery in large vessel stroke
1. Adding a thrombolytic agent delivered through the arterial catheter immediately following mechanical clot extraction increased near-complete functional recovery at three months. 2. Rates of symptomatic brain bleeding did not...
A lower volume of polyethylene glycol with ascorbate (MoviPrep) may improve bowel cleansing prior to colonoscopy
1. 1 litre polyethylene glycol with ascorbate (1L-PEG-Asc) showed superior bowel cleansing efficacy compared to 2 litre polyethylene glycol with ascorbate (2L-PEG-Asc) in adult patients undergoing colonoscopy for colorectal cancer...
Thrombectomy may improve functional independence in acute ischemic stroke with medium vessel occlusion
1. In this randomized controlled trial, acute stroke patients with medium-vessel occlusion and moderate-to-severe neurological deficits who received thrombectomy in addition to medical management were more likely to achieve functional...
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Explore the Classics Series™
EAST-AFNET 4 Trial: Early Rhythm Control vs Usual Care in Atrial Fibrillation (East AF) [Classics Series]
1. The EAST-AFNET 4 trial (East AF) demonstrated that early rhythm control therapy—including antiarrhythmic drugs or catheter ablation—was associated...
Ablation may reduce stroke risk, death, heart failure hospitalization in patients with atrial fibrillation
1. In this systematic review and meta-analysis, catheter ablation was found to reduce overall risk of ischemic stroke, hospitalization...
Breast cancer survivors may have a lower risk of Alzheimer’s dementia
1. In this retrospective cohort study, breast cancer survivors had a lower risk of Alzheimer’s dementia compared with cancer-free...
Repeated medial branch blocks do not improve pain outcomes for thermal radiofrequency ablation
1. For patients with facet-mediated spine pain that achieve ≥80% pain relief after a medial branch block, a second...
