Anitocabtagene autoleucel associated with sustained clinical response in heavily pretreated multiple myeloma
1. In this phase 1 trial involving patients with triple-class refractory multiple myeloma, treatment with anitocabtagene autoleucel led to a complete response in more than three-quarters of participants. 2. At...
Gene therapy shows sustained benefit in Wiskott–Aldrich syndrome
1. In this analysis of data from over two dozen individuals with Wiskott-Aldrich syndrome, treatment with etuvetidigene autotemcel (etu-cel) was associated with lower frequency of severe infections and moderate or...
Use of long-acting broadly neutralizing antibodies may delay human immunodeficiency virus (HIV) rebound following discontinuation of antiretroviral therapy
1. In this large randomized controlled trial, patients with human immunodeficiency virus (HIV) who received long-acting broadly neutralizing antibodies were able to delay HIV viral load rebound when off of...
Large language models (LLMs) demonstrated the ability to generate accurate research manuscripts but required human oversight for more complex analyses
1. Ifargan and colleagues developed a platform that guides LLMs to annotate research data and produce comprehensive research papers. 2. The platform demonstrated reliability for simpler tasks, such as creating...
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Explore the Classics Series™
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EAST-AFNET 4 Trial: Early Rhythm Control vs Usual Care in Atrial Fibrillation (East AF) [Classics Series]
1. The EAST-AFNET 4 trial (East AF) demonstrated that early rhythm control therapy—including antiarrhythmic drugs or catheter ablation—was associated...
ABCD2 Score: Predicting Early Stroke Risk After Transient Ischemic Attack (TIA) [Classics Series]
1. The ABCD2 score is a validated clinical tool that estimates the short-term risk of stroke following a transient...
Child-Pugh Score: Prognosis, Classification & Cirrhosis Staging in Chronic Liver Disease [Classics Series]
1. The Child-Pugh score, derived from five clinical and lab measures (bilirubin, albumin, INR/prothrombin time, ascites, encephalopathy), is widely...
POISE Trial: Perioperative Metoprolol Reduces MI but Increases Stroke & Mortality [Classics Series]
1. In adults undergoing noncardiac surgery, perioperative β-blocker therapy with extended-release metoprolol significantly reduced nonfatal myocardial infarction (MI) risk...
