2 Minute Medicine

1. In this phase 3, randomized, placebo-controlled trial, an antiviral medication approved for treating smallpox (tecovirimat) did not accelerate clinical resolution of mpox compared to placebo.  2. Tecovirimat also did...

1. In a randomized phase 2–3 trial of patients with resectable high-risk intrahepatic cholangiocarcinoma, neoadjuvant therapy with gemcitabine–oxaliplatin, lenvatinib, and an anti programmed death-1 antibody prior to curative resection significantly...

1. Sivelestat significantly reduced the incidence of postoperative acute respiratory distress syndrome (ARDS) compared to placebo in adult patients undergoing cardiac surgery requiring cardiopulmonary bypass (CPB). Evidence Rating Level: 1...

1. Alcohol misuse among older adults is common but the delivery of evidence-based interventions such as referral services and pharmacotherapy remains low in the emergency department (ED). Evidence Rating Level:...