Evaluating pediatric sinus antibiotics: effectiveness and safety comparison
1. There is no significant difference in treatment failure between pediatric patients taking amoxicillin versus amoxicillin-clavulanate for acute sinusitis. 2....
Neuropathologic and psychological changes present in young athletes with repetitive head impacts
1. Young amateur and professional contact sport athletes are at risk of developing long-term neurodegenerative disorders, such as chronic traumatic...
Prenatal magnesium at 30-34 weeks does not reduce risk of death or cerebral palsy: MAGENTA trial
1. Efficacy: There was no significant difference in death or cerebral palsy at 2 years between those who received magnesium...
School-based cardiovascular health promotion program trial had neutral effect on adolescent cardiovascular health
1. There was no difference in cardiovascular health between adolescents who received a 2 or 4-year-long school-based health promotion intervention...
Antibiotic stewardship in children with acute sinusitis via nasopharyngeal testing
1. For children suffering from acute sinusitis, administering antibiotics showed limited advantages for those without nasopharyngeal bacterial pathogens at the...
Butylphthalide is an effective and safe neuroprotective agent for acute ischemic stroke– the BAST trial
1. Butylphthalide is effective -- the BAST trial showed that butylphthalide is associated with more favorable functional outcomes compared to...
No advantage of continuous vs intermittent meropenem in critically ill patients – the MERCY trial
1. The MERCY trial revealed that continuous infusion of meropenem does not confer a significant advantage over intermittent administration in...
Upadacitinib is safe and effective in adolescents with moderate-to-severe atopic dermatitis
1. Upadacitinib, a new once-daily oral systemic medication, reduces eczema severity and improves clinician- and patient-reported measures in adolescents with...
Increased risk of mortality and epilepsy in individuals post-stroke
1. In this cohort study, it was found that acute symptomatic status epilepticus is associated with a higher risk of...
Novel neuroanatomical endophenotypes identified in autism spectrum disorder
1. In this cross-sectional study with 669 individuals, a 3-dimensional endophenotype was identified to elucidate the neuroanatomical, clinical and genetic...