Reduced pneumococcal vaccine schedules non-inferior to WHO recommendations
1. In this cluster-randomized controlled trial, it was found that a pneumococcal conjugate vaccine (PCV) schedule involving a single primary...
![Maternal cell-free DNA sequencing superior to standard aneuploidy screening [CARE Study]](https://www.2minutemedicine.com/wp-content/uploads/2014/02/47-karyotype-350x250.jpg)
Australian couple-based genetic screening program feasible and accepted
1. In this prospective cohort study, genetic screening among Australian reproductive couples was widely accepted and associated with low decisional...
Inavolisib lengthens progression-free survival time in HER2-negative advanced breast cancer
1. In this randomized controlled trial, in patients with PIK3CA-mutated advanced breast cancer, the addition of inavolisib to a palbociclib-fulvestrant...
Invasive treatment not superior to medical therapy in older adults with NSTEMI
1. In this randomized controlled trial, in older adults with non-ST-segment elevation myocardial infarction (NSTEMI), invasive treatment did not significantly...
Finerenone reduces heart failure events in patients with HFpEF
1. In this randomized controlled trial of patients with heart failure and mildly decreased or preserved ejection fraction, finerenone treatment...
Nivolumab+AVD improves progression-free survival in advanced-stage Hodgkin lymphoma
1. This randomized controlled trial found that in patients with newly diagnosed stage III or IV Hodgkin lymphoma, treatment with...
![Engineered stem cells mitigate liver damage caused by radiation [PreClinical]](https://www.2minutemedicine.com/wp-content/uploads/2014/12/Human_embryonic_stem_cells-350x250.png)
Lentiviral gene therapy prevents functional deterioration in cerebral adrenoleukodystrophy patients
1. In this prospective cohort study, in boys with diagnosed cerebral adrenoleukodystrophy, it was found that lentiviral gene therapy containing...
Tirzepatide reduces obstructive sleep apnea symptoms and associated risks
1. In this randomized controlled trial, in patients with both moderate-severe obstructive sleep apnea (OSA) and obesity, it was found...
MRI-informed biopsy recommendation reduces overdiagnosis in prostate cancer screening
1. In this randomized controlled trial of men aged 50 to 60, forgoing prostate biopsies in those with elevated PSA...
Communities That HEAL intervention does not reduce opioid-related mortality
1. In this cluster-randomized controlled trial, in communities with a high rate of opioid-related overdoses, the implementation of the Communities...