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The DOSE trial: Loop diuretic strategies in acute decompensated heart failure [Classics Series]
1. The use of loop diuretics in acute decompensated heart failure is commonplace, but clinical practice varies widely with regards...
Rising price of health services drove increase in US health care spending
1. This ecological study found that between 1996-2013, annual US health care spending was largely related to increases in health...
Anti-TNF agents and thiopurines are associated with a slight increase in lymphoma in IBD patients
1. In this retrospective cohort study, inflammatory bowel disease (IBD) patients on anti-tumor necrosis factor (TNF) agents or thiopurines had...
Blood transfusions from ever-pregnant donors may increase mortality in male patients
1. In this retrospective analysis, there was a slight increase in male patient mortality per transfusion when receiving blood from...
Semaglutide results in better glycemic control than placebo in diabetes
1. This randomized clinical trial showed that, among patients with type 2 diabetes, oral semaglutide resulted in better glycemic control...
Supplemental oxygen does not reduce mortality in stroke patients
1. This randomized clinical trial showed that among patients with acute stroke, supplementary low-dose oxygen for 72 hours (either nocturnal...
Mortality rates in the US from respiratory diseases increased from 1980 to 2014
1. In this retrospective analysis of mortality data from a number of national databases, the mortality rates from respiratory diseases...
Sentinel lymph node dissection not inferior to complete axillary lymph node dissection for women with nodal involvement of breast cancer
1. For women with invasive breast cancer and metastases to 1 or 2 sentinel lymph nodes, treatment with sentinel lymph...
Hormone replacement therapy not associated with changes in mortality in post-menopausal women
1. In this analysis of two randomized controlled trials, hormone replacement therapy (HRT) was not associated with a change in...
High recurrence of gastroesophageal reflux disease in patients treated with laparoscopic antireflux surgery
1. Among patients receiving laparoscopic antireflux surgery, 17.7% experienced recurrent GERD requiring medication or secondary antireflux surgery 2. Factors associated...