• About
  • Masthead
  • License Content
  • Advertise
  • Submit Press Release
  • RSS/Email List
  • 2MM Podcast
  • Write for us
  • Contact Us
2 Minute Medicine
No Result
View All Result

No products in the cart.

SUBSCRIBE
  • Specialties
    • All Specialties, All Recent Reports
    • Cardiology
    • Chronic Disease
    • Dermatology
    • Emergency
    • Endocrinology
    • Gastroenterology
    • Imaging and Intervention
    • Infectious Disease
    • Nephrology
    • Neurology
    • Obstetrics
    • Oncology
    • Ophthalmology
    • Pediatrics
    • Pharma
    • Preclinical
    • Psychiatry
    • Public Health
    • Pulmonology
    • Rheumatology
    • Surgery
  • AI Roundup
  • Pharma
  • The Scan+
  • Classics™+
    • 2MM+ Online Access
    • Paperback and Ebook
  • Rewinds
  • Visual
  • Podcasts
  • Partners
    • License Content
    • Submit Press Release
    • Advertise with Us
  • Account
    • Subscribe
    • Sign-in
    • My account
2 Minute Medicine
  • Specialties
    • All Specialties, All Recent Reports
    • Cardiology
    • Chronic Disease
    • Dermatology
    • Emergency
    • Endocrinology
    • Gastroenterology
    • Imaging and Intervention
    • Infectious Disease
    • Nephrology
    • Neurology
    • Obstetrics
    • Oncology
    • Ophthalmology
    • Pediatrics
    • Pharma
    • Preclinical
    • Psychiatry
    • Public Health
    • Pulmonology
    • Rheumatology
    • Surgery
  • AI Roundup
  • Pharma
  • The Scan+
  • Classics™+
    • 2MM+ Online Access
    • Paperback and Ebook
  • Rewinds
  • Visual
  • Podcasts
  • Partners
    • License Content
    • Submit Press Release
    • Advertise with Us
  • Account
    • Subscribe
    • Sign-in
    • My account
SUBSCRIBE
2 Minute Medicine
Subscribe
Home All Specialties Oncology

Brachytherapy following sublobar resection did not reduce local NSCLC recurrence

byMonica ParksandAndrew Bishara
July 4, 2014
in Oncology, Pulmonology
Reading Time: 2 mins read
0
Share on FacebookShare on Twitter

1. Brachytherapy following sublobar resection (BSR) had no significant association with local NSCLC recurrence compared to sublobar resection (SR) alone.

2. Three-year overall survival rates were similar between BSR and SR.

Evidence rating level: 1 (Excellent)

Study Rundown: Compared to lobectomy, sublobar resection for non-small-cell lung cancer (NSCLC) is associated with greater risk for local recurrence. Adjuvant radiation therapy may reduce the risk of recurrence, and intraoperative brachytherapy offers greater patient adherence and minimal radiation injury compared to external-beam radiotherapy. At the conclusion of this prospective trial, the authors found that there was no relationship between adjuvant brachytherapy and rates of local recurrence. Though there was a trend towards reduced recurrence among patients with potentially compromised tumor margins who underwent brachytherapy, it was not statistically significant. Three year all-cause mortality also did not differ between the two treatment arms. Based on these findings, the authors suggested that adjuvant brachytherapy may be most beneficial only for patients with compromised margins following resection. It should be noted that this study was underpowered to detect smaller therapeutic benefits, and there was a lower rate of local recurrence in this trial compared to previous trials.

Click to read the study in JCO

Relevant Reading: Limited resection for non-small cell lung cancer: observed local control with implantation of I-125 brachytherapy seeds

RELATED REPORTS

Structured exercise intervention improves survival in colon cancer patients

2 Minute Medicine: Pharma Roundup – Gastric Immunotherapy Gains, Prostate Pill Expansion, Five-Minute Myeloma Dosing, and Streamlined CAR-T Access [July 8th 2025]

Tumor-infiltrating clonal hematopoiesis is associated with NSCLC recurrence

In-Depth [randomized controlled trial]: The authors randomized a total of 224 patients with high-risk operable non small cell lung cancer (NSCLC) <3cm to either sublobar resection alone or sublobar resection followed by brachytherapy. The primary outcome measured was time to local recurrence in the primary tumor lobe or in ipsilateral hilar nodes. This study was powered to detect large HR 0.315. Median follow-up was 4.38 years. A total of 222 patients were available for intention-to-treat analysis. There was no difference in time to local recurrence (HR, 1.01; 95% CI, 0.51 to 1.98, P = 0.98). There was a non-statistically significant trend to reduced local recurrence among patients with potentially compromised tumor margins following surgery (HR, 0.22; P = 0.24). Three year overall survival rates were similar between the two treatment arms (71% and 71%, P = 0.97).

Image: PD

©2012-2014 2minutemedicine.com. All rights reserved. No works may be reproduced without expressed written consent from 2minutemedicine.com. Disclaimer: We present factual information directly from peer reviewed medical journals. No post should be construed as medical advice and is not intended as such by the authors, editors, staff or by 2minutemedicine.com. PLEASE SEE A HEALTHCARE PROVIDER IN YOUR AREA IF YOU SEEK MEDICAL ADVICE OF ANY SORT. 

Tags: brachytherapylung cancernon-small cell lung canceroncologysublobar resectionsurvival
Previous Post

No association found between time to appendectomy and appendix perforation

Next Post

Eosinophilic infiltrates have limited diagnostic utility in alopecia areata

RelatedReports

Development of a risk index for colorectal cancer screening
Gastroenterology

Structured exercise intervention improves survival in colon cancer patients

July 9, 2025
2 Minute Medicine: Pharma Roundup: Price Hikes, Breakthrough Approvals, Legal Showdowns, Biotech Expansion, and Europe’s Pricing Debate [May 12nd, 2025]
Pharma

2 Minute Medicine: Pharma Roundup – Gastric Immunotherapy Gains, Prostate Pill Expansion, Five-Minute Myeloma Dosing, and Streamlined CAR-T Access [July 8th 2025]

July 8, 2025
Lessons from real-world implementation of lung cancer screening
Oncology

Tumor-infiltrating clonal hematopoiesis is associated with NSCLC recurrence

July 7, 2025
All Specialties

Minimally invasive surgery is beneficial for epithelial ovarian cancer 

July 4, 2025
Next Post
Eosinophilic infiltrates have limited diagnostic utility in alopecia areata

Eosinophilic infiltrates have limited diagnostic utility in alopecia areata

TV associated with higher BMI in teens

Unhealthy food cues prominent in children’s programming in the UK and Ireland

Classics Series, Landmark Trials in Medicine

The TORCH trial: Combination of salmeterol and fluticasone in treating COPD [Classics Series]

2 Minute Medicine® is an award winning, physician-run, expert medical media company. Our content is curated, written and edited by practicing health professionals who have clinical and scientific expertise in their field of reporting. Our editorial management team is comprised of highly-trained MD physicians. Join numerous brands, companies, and hospitals who trust our licensed content.

Recent Reports

  • Oral vancomycin may be effective for pouchitis in inflammatory bowel disease
  • Inebilizumab improves outcome in patients generalized myasthenia gravis
  • Medbridge turns any phone into a motion-capture coach for at-home rehab
License Content
Terms of Use | Disclaimer
Cookie Policy
Privacy Statement (EU)
Disclaimer

© 2021 2 Minute Medicine, Inc. - Physician-written medical news.

  • Specialties
    • All Specialties, All Recent Reports
    • Cardiology
    • Chronic Disease
    • Dermatology
    • Emergency
    • Endocrinology
    • Gastroenterology
    • Imaging and Intervention
    • Infectious Disease
    • Nephrology
    • Neurology
    • Obstetrics
    • Oncology
    • Ophthalmology
    • Pediatrics
    • Pharma
    • Preclinical
    • Psychiatry
    • Public Health
    • Pulmonology
    • Rheumatology
    • Surgery
  • AI Roundup
  • Pharma
  • The Scan
  • Classics™
    • 2MM+ Online Access
    • Paperback and Ebook
  • Rewinds
  • Visual
  • Podcasts
  • Partners
    • License Content
    • Submit Press Release
    • Advertise with Us
  • Account
    • Subscribe
    • Sign-in
    • My account
No Result
View All Result

© 2021 2 Minute Medicine, Inc. - Physician-written medical news.