Anti-CD38 monoclonal antibody improves platelet counts in immune thrombocytopenia
1. In this randomized controlled trial, CM313, an anti-CD38 monoclonal antibody therapy, was associated with rapid recovery of platelet counts...
Hematology
Andexanet reduces hematoma expansion in factor Xa inhibitor-associated intracerebral hemorrhage
1. In this randomized controlled trial, among patients presenting with acute intracerebral hemorrhage (ICH) who had taken factor Xa inhibitors,...
Prophylactic therapy with recombinant ADAMTS13 safe for congenital TTP
1. In this randomized controlled trial, among individuals with congenital thrombotic thrombocytopenic purpura (TTP), no patients in a prophylactic group...
Multivariate predictive model for bone marrow sampling in MGUS patients
1. A multivariate predictive model was developed to help determine when a bone marrow sample would help distinguish between patients...
Low-molecular weight heparin bridging therapy safe in elderly undergoing surgery following percutaneous coronary intervention
Impact of perioperative low-molecular-weight heparin therapy on clinical events of elderly patients with prior coronary stents implanted > 12 months...
Mitoxantrone is superior to liposomal daunorubicin in MRD (measurable residual disease)-guided treatment of AML in pediatric cases
1. Mitoxantrone enhances five-year event-free survival over liposomal daunorubicin in MRD-guided pediatric AML treatment. 2.High-risk patients identified by MRD guidance...
Novel prophylactic anticoagulation scoring tool helps stratify patients following lower limb trauma
1. The 3-month symptomatic venous thromboembolism rate was 0.7% in patients with TRiP(cast) score < 7 and not receiving anticoagulation....
Iptacopan improves hematologic and clinical outcomes in paroxysmal nocturnal hemoglobinuria
1. In two clinical trials, iptacopan in patients with paroxysmal nocturnal hemoglobinuria (PNH) improved hemoglobin levels compared to anti-C5-treated patients...
Concomitant selective serotonin reuptake inhibitors and oral anticoagulants may increase risk of bleeding
1. This case-control study found that in patients with atrial fibrillation concomitant Serotonin Reuptake Inhibitor (SSRI) and Oral Anticoagulants (OAC)...
Imetelstat improves blood transfusion independence in lower-risk myelodysplastic syndromes
1. Significantly more patients in the imetelstat group achieved RBC transfusion independence at 8 weeks after treatment compared to placebo....