Stereotactic radiotherapy reduces anti-VEGF injection requirements in neovascular age-related macular degeneration
1. Fewer anti-VEGF intravitreal injections were required in the SRT group over 2 years. 2. Change in visual acuity was...
Ophthalmology
Reports of high-impact ophthalmology studies by medical professionals
Gene editing improves photoreceptor function in CEP290-associated retinal degeneration
1. In this randomized controlled trial, among patients with centrosomal protein 290 (CEP290)-associated retinal degeneration, subretinal injection of EDIT-101 resulted...
High dose aflibercept may be promising for treatment of age-related macular degeneration
1. Aflibercept 8 mg was non-inferior to 2 mg for best-corrected visual acuity at 48 weeks. 2. Ocular adverse events...
High dose aflibercept reduced treatment burden in patients with diabetic macular edema
1. Aflibercept 8 mg was non-inferior to 2 mg for best-corrected visual acuity at 48 weeks. 2. Ocular adverse events...
Avacincaptad pegol reduces the rate of age-related macular degeneration in geographic atrophy
1. Avacincaptad pegol significantly slowed geographic atrophy over 12 months. 2. Exudative macular neovascularization was comparable among treatment groups. Evidence...
Immediate bilateral cataract surgery is more cost-effective with similar outcomes compared to delayed sequential surgery
1. Target refractive outcome was achieved in 97% of ISBCS and 98% of DSBCS patients. 2. Societal costs for ISBCS...
Retinopathy of prematurity may account for a large proportion of childhood blindness in the United States
1. In a cross-sectional study using a large clinical registry, retinopathy of prematurity was the most common cause of blindness...
Retinal optical coherence tomography (OCT) measurements may be associated with genetic Alzheimer’s disease risk
1. In a retrospective study examining 50,000 optical coherence tomography (OCT) images from a large database, thicknesses of several different...
Novel anti-VEGF agent provides additional benefit when combined with ranibizumab for neovascular age-related macular degeneration
1. In a phase 2 randomized trial, intravitreal injection with both ranibizumab and OPT-302, a VEGF-C and -D inhibitor, led...
Glucagon-like peptide-1 receptor agonist may reduce incidence of diabetic retinopathy
1. Patients with Type 2 Diabetes taking glucagon-like peptide-1 receptor agonists (GLP-1 RAs) have a lower incidence of diabetic retinopathy...