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Home All Specialties Chronic Disease

Paretic limbs suffer greater loss of bone mineral density following stroke

byPaary BalakumarandAlex Chan
May 19, 2025
in Chronic Disease, Neurology, Rheumatology
Reading Time: 2 mins read
Quick Take: Functional Outcome of Intravenous Thrombolysis in Patients With Lacunar Infarcts in the WAKE-UP Trial
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1. BMD may differ on paretic and nonparetic sides in stroke patients with a history of falling and balance deficits

Evidence Rating Level: 2 (Good) 

There is an increased risk of fracture due to poststroke osteoporosis. These injuries particularly affect the hip. However, current recommendations rarely recommend bone mineral density (BMD) measurements as a follow-up in the management of this patient population. This cross-sectional study aimed to compare the femoral hip BMD between the “fallers” and “nonfallers” in stroke patients. BMD was measured at the femoral neck using dual-energy x-ray absorptiometry. Additionally, the study aimed to identify any differences in balance (Berg balance scale (BBS)), mobility, fear of falling (falls efficacy scale-international (FES-I)), and exploring discrepancies between paretic and noparetic sides within each group. Of the 44 enrolled patients, 22 reported falling. No significant difference was seen between BMD in paretic femoral neck, nonparetic femoral neck, and lumbar spine between the fallers and nonfallers (p = .504, p = .197, p = .667, respectively). T-scores followed a similar trend (p = .457, p = .194, p = .693, respectively). Additionally, there was a significant difference between the BMD and T-score bilaterally in fallers (p = .007, 95% CI −0.06 to −0.01; p = .006, 95% CI −0.51 to −0.09) but not in nonfallers. Balance (BBS) was significantly lower in fallers (p = .033, 95% confidence interval [CI] 0.17–19.05). Fear of falling (FES-I) was significantly higher in fallers as well (p = .001, 95% CI −22.40 to −6.50).

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EvidencePulse™ by 2 Minute Medicine 2026 evidence scan 3 reports You asked top stroke trials 2026 Synthesizing medical evidence... Top 2026 stroke trial results: OCEANIC — ischemic stroke: 6.2% vs 8.4% OPTION* — mRS 0–1: 43.6% vs 34.2% ORIENTAL* — mRS 0–2: 58.6% vs 46.6% *Higher sICH in intervention arms Participants randomizedN OCEANIC 12,327 OPTION 570 ORIENTAL 564 Ask about guidelines or landmark trials... ↑ Try EvidencePulse™ Ask the evidence.
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