Praxis Precision’s relutrigine reduces seizures in rare epileptic disorders in phase 2 clinical trials
Relutrigine resulted in a 46% reduction in seizures and seizure freedom in 30% of patients. Patients also experienced meaningful improvements ...
Tag: Seizure
Artificial intelligence may improve the accuracy of physicians’ electroencephalogram interpretations
1. A cross-over study compared clinicians’ electroencephalogram (EEG) interpretation accuracy with artificial intelligence (AI) assistance against the same participants without ...
Topiramate for prenatal antiseizure therapy is not associated autism spectrum disorder
1. In this retrospective cohort study, exposure to antiseizure medications was associated with a higher incidence of autism spectrum disorder ...
Higher blood pressure targets do not improve outcomes in comatose patients
1. Comatose patients with a low blood pressure target did not significantly differ in rates of mortality or poor neurological ...
Prenatal exposure to antiseizure medication associated with increased risk of autism and intellectual disability
1. In this population-based cohort study, prenatal exposure to topiramate and valproate monotherapy was associated with increased risk of autism ...
New prognostication tool predicts neurological deficits and long-term survival in patients with status epilepticus
1. In this retrospective cohort study, among 261 patients with status epilepticus, age, duration, and nonconvlusive status epilepticus in coma ...
Pregnant patients with epilepsy may benefit from increased doses of anticonvulsant medications
1. In this observational cohort study, women with epilepsy experienced significant decreases in serum levels of their prescribed anticonvulsant medications ...
Early treatment of seizures in newborns associated with decreased seizure burden and frequency.
Neonatal seizure management – Is the timing of treatment critical? 1. In a cohort of newborn infants, treatment of seizures ...
Short-term seizure prophylaxis maximizes quality-adjusted life-years in simulated spontaneous intracerebral hemorrhage patients
1. A risk-guided strategy of using short-term secondary prophylaxis in intracerebral hemorrhage patients, and long-term secondary therapy after late seizures, ...
Levetiracetam not clinically effective nor cost-effective compared to valproate for newly diagnosed generalized or unclassified epilepsy
1. 12-month remission was superior with valproate than with levetiracetam. 2. Compared to levetiracetam, patients in the valproate group reported ...