• About
  • Masthead
  • License Content
  • Advertise
  • Submit Press Release
  • RSS/Email List
  • 2MM Podcast
  • Write for us
  • Contact Us
2 Minute Medicine
No Result
View All Result

No products in the cart.

SUBSCRIBE
  • Specialties
    • All Specialties, All Recent Reports
    • Cardiology
    • Chronic Disease
    • Dermatology
    • Emergency
    • Endocrinology
    • Gastroenterology
    • Imaging and Intervention
    • Infectious Disease
    • Nephrology
    • Neurology
    • Obstetrics
    • Oncology
    • Ophthalmology
    • Pediatrics
    • Pharma
    • Preclinical
    • Psychiatry
    • Public Health
    • Pulmonology
    • Rheumatology
    • Surgery
  • AI Roundup
  • Pharma
  • The Scan+
  • Classics™+
    • 2MM+ Online Access
    • Paperback and Ebook
  • Rewinds
  • Visual
  • Podcasts
  • Partners
    • License Content
    • Submit Press Release
    • Advertise with Us
  • Account
    • Subscribe
    • Sign-in
    • My account
2 Minute Medicine
  • Specialties
    • All Specialties, All Recent Reports
    • Cardiology
    • Chronic Disease
    • Dermatology
    • Emergency
    • Endocrinology
    • Gastroenterology
    • Imaging and Intervention
    • Infectious Disease
    • Nephrology
    • Neurology
    • Obstetrics
    • Oncology
    • Ophthalmology
    • Pediatrics
    • Pharma
    • Preclinical
    • Psychiatry
    • Public Health
    • Pulmonology
    • Rheumatology
    • Surgery
  • AI Roundup
  • Pharma
  • The Scan+
  • Classics™+
    • 2MM+ Online Access
    • Paperback and Ebook
  • Rewinds
  • Visual
  • Podcasts
  • Partners
    • License Content
    • Submit Press Release
    • Advertise with Us
  • Account
    • Subscribe
    • Sign-in
    • My account
SUBSCRIBE
2 Minute Medicine
Subscribe
Home All Specialties Cardiology

Ticagrelor and clopidogrel have similar major bleeding rates following thrombolytic therapy

byJames EnglandandAnees Daud
March 19, 2018
in Cardiology, Emergency, Imaging and Intervention, Neurology
Reading Time: 2 mins read
0
Share on FacebookShare on Twitter

1. Use of ticagrelor resulted in similar rates of major bleeding compared to clopidogrel in patients with ST elevation myocardial infarction treated with thrombolysis.

Evidence Rating Level: 2 (Good)

Study Rundown: Antiplatelet therapy is a major component of management of acute myocardial infarction. Ticagrelor results in greater and more rapid P2Y12 inhibition than clopidogrel and is shown to have a reduction in mortality from vascular events following percutaneous coronary intervention (PCI). Patients treated with fibrinolytic therapy have not been directly studied with ticagrelor because of concern for an increase in bleeding risk. This study was an open label randomized controlled trial of ticagrelor or clopidogrel for antiplatelet therapy following pharmacologic thrombolysis. The study found that at thirty days, ticagrelor was non-inferior to clopidogrel with respect to major bleeding. Minor and minimal bleeding were more common in the ticagrelor group.

The major limitation of the study was the use of clopidogrel up front prior to randomization, not allowing any conclusions to be drawn about the safety of ticagrelor first line for myocardial infarction in centers where PCI cannot be performed first line. In addition, the trial only included patients younger than 75 years, a population at lower risk for major bleeding events.

Click to read the study, published in JAMA Cardiology

Relevant Reading: Ticagrelor versus clopidogrel is associated with better recovery of LV function after Acute Myocardial Infarction

RELATED REPORTS

De-escalating dual antiplatelet therapy may lower major bleeding risk following drug-eluting stent implantation

Intra-arterial tenecteplase has limited use after successful endovascular recanalisation of acute posterior circulation arterial occlusion

The association between serum S100β levels and prognosis in acute stroke patients after intravenous thrombolysis

In-Depth [randomized controlled trial]: This study was a multicenter, open label, randomized controlled trial that enrolled patients with acute ST-elevation myocardial infarction under the age of 75 years, who received fibrinolytic therapy. Patients were excluded if there was a contraindication to clopidogrel, use of anticoagulation, risk of bradycardia, or use of a cytochrome P450 3A inhibitor. Patients were treated with ticagrelor (180 mg loading, then 90 mg twice daily) or clopidogrel (300-600 mg loading dose, 75 mg daily).

Major bleeding at 30 days, per thrombolysis in myocardial infarction (TIMI) major bleeding criteria, occurred in 0.73% of patients receiving ticagrelor and 0.69% of those receiving clopidogrel (absolute difference, 0.04%; 95%CI, −0.49% to 0.58%; p < 0.001 for noninferiority). Fatal (0.16% vs 0.11%; p = 0.67) and intracranial (0.42%vs 0.37%; p = 0.82) bleeding events were not different between the study groups. Minor bleeding occurred in 3.24% of ticagrelor patients and 2.01% of clopidogrel patients (p = 0.02).

Image: PD

©2018 2 Minute Medicine, Inc. All rights reserved. No works may be reproduced without expressed written consent from 2 Minute Medicine, Inc. Inquire about licensing here. No article should be construed as medical advice and is not intended as such by the authors or by 2 Minute Medicine, Inc.

Tags: clopidogrelthrombolysisTicagrelor
Previous Post

Administrative costs, provider salaries, and pharmaceutical prices drive higher healthcare spending in the United States

Next Post

Hemodynamic markers of pulmonary hypertension in heart failure with preserved ejection fraction are associated with mortality

RelatedReports

Stent type may not be related to adverse cardiac events after surgery
Cardiology

De-escalating dual antiplatelet therapy may lower major bleeding risk following drug-eluting stent implantation

February 17, 2025
Non-alcoholic fatty liver disease and risk of incident acute myocardial infarction and stroke: findings from matched cohort study of 18 million European adults
Emergency

Intra-arterial tenecteplase has limited use after successful endovascular recanalisation of acute posterior circulation arterial occlusion

January 22, 2025
Intensive rehabilitation not superior to traditional therapy for arm function after stroke
Cardiology

The association between serum S100β levels and prognosis in acute stroke patients after intravenous thrombolysis

October 11, 2024
Non-alcoholic fatty liver disease and risk of incident acute myocardial infarction and stroke: findings from matched cohort study of 18 million European adults
Emergency

Adjunctive treatment with argatroban or eptifibatide does not improve post-stroke functional outcomes

October 1, 2024
Next Post
Long-term outcomes for off-pump and on-pump CABG are similar

Hemodynamic markers of pulmonary hypertension in heart failure with preserved ejection fraction are associated with mortality

Engineered stem cells mitigate liver damage caused by radiation [PreClinical]

Human neural stem cell grafts in rhesus monkeys improve motor function after spinal cord injury [PreClinical]

Microcephaly rates elevated in Brazil prior to Zika virus epidemic

Early intrauterine Zika infection linked to birth defects among infants in the US French Territories

2 Minute Medicine® is an award winning, physician-run, expert medical media company. Our content is curated, written and edited by practicing health professionals who have clinical and scientific expertise in their field of reporting. Our editorial management team is comprised of highly-trained MD physicians. Join numerous brands, companies, and hospitals who trust our licensed content.

Recent Reports

  • Inebilizumab improves outcome in patients generalized myasthenia gravis
  • Medbridge turns any phone into a motion-capture coach for at-home rehab
  • Structured exercise intervention improves survival in colon cancer patients
License Content
Terms of Use | Disclaimer
Cookie Policy
Privacy Statement (EU)
Disclaimer

© 2021 2 Minute Medicine, Inc. - Physician-written medical news.

  • Specialties
    • All Specialties, All Recent Reports
    • Cardiology
    • Chronic Disease
    • Dermatology
    • Emergency
    • Endocrinology
    • Gastroenterology
    • Imaging and Intervention
    • Infectious Disease
    • Nephrology
    • Neurology
    • Obstetrics
    • Oncology
    • Ophthalmology
    • Pediatrics
    • Pharma
    • Preclinical
    • Psychiatry
    • Public Health
    • Pulmonology
    • Rheumatology
    • Surgery
  • AI Roundup
  • Pharma
  • The Scan
  • Classics™
    • 2MM+ Online Access
    • Paperback and Ebook
  • Rewinds
  • Visual
  • Podcasts
  • Partners
    • License Content
    • Submit Press Release
    • Advertise with Us
  • Account
    • Subscribe
    • Sign-in
    • My account
No Result
View All Result

© 2021 2 Minute Medicine, Inc. - Physician-written medical news.